See also GuiProgramming for a full list of toolkits.
pyFLTK
Pygame
- you are in full control
- you are responsible for everything
- only one window
PyGTK
- powerful - aims to be a 1:1 GTK wrapper
- good GTK docs out there for both C and Python
- it's a wrapper - sometimes C idioms leak through
Pyglet
- new
- OpenGL-y (3D)
PyQT
PythonCard
Tkinter
- standard GUI toolkit included with Python
- simple and easy
currently-installed version probably doesn't support antialiased text yet
wxPython
- cross platform
- doesn't always look the same though